I also am co-author of a number of other articles, ranging from my undergraduate work to collaborations during my PhD research and post-doc. These collaborations and co-authorships were in many different biological disciplines, reflecting my broad interest in biology. From neuroscience to human genetics, from fundamental cancer to cystic fibrosis research. 

Neuroscience: de Lange RP, de Roos AD, Borst JG (2003) Two modes of vesicle recycling in the rat calyx of Held. J Neurosci 23:10164-73. For the work I did in Amsterdam with Gerard Borst on auditory nerve cells. Simultaneous single cell imaging and patch clamp in brain slices.

Pharmacology: Harks EG, de Roos AD, Peters PH, de Haan LH, Brouwer A, Ypey DL, van Zoelen EJ, Theuvenet AP (2001) Fenamates: a novel class of reversible gap junction blockers. J Pharmacol Exp Ther 298:1033-41. From the graduate student that continued my PhD research in Lex Theuvenet’s laboratory. Turned out to be very fruitful research by Erik Harks.

Experimental Physics: Parak WJ, Domke J, George M, Kardinal A, Radmacher M, Gaub HE, de Roos AD, Theuvenet AP, Wiegand G, Sackmann E, Behrends JC (1999) Electrically excitable normal rat kidney fibroblasts: A new model system for cell-semiconductor hybrids. Biophys J 76:1659-67. Collaboration with Wolfgang Parak in Hermann Gaub’s lab in Munich where we grew cells on silicon wafers. Since wafers are not translucent, we had to perform patch clamping without the image of the cells. Cool stuff!

Cell Biology: Lenferink AE, De Roos AD, Van Vugt MJ, Van de Poll ML, Van Zoelen EJ (1998) The linear C-terminal regions of epidermal growth factor (EGF) and transforming growth factor-alpha bind to different epitopes on the human EGF receptor. Biochem J 336:147-51. Growth factor research was the main topic of van Zoelen’s department, including molecular characterization of receptors as possible targets for cancer therapy. The ability to release second messengers such as IP3 was used as a bioassay for fucntionality.

Physiology and Biophysics: Schultz BD, DeRoos AD, Venglarik CJ, Singh AK, Frizzell RA, Bridges RJ (1996) Glibenclamide blockade of CFTR chloride channels. Am J Physiol 271:L192-200. From my stay in Birmingham Alabama in Bob Bridges’ and Ray Frizzell’s lab, for the single-channel patch clamping. Bruce Schultz showed me the ins and outs of patch clamping and I used this to study CTFR chloride channels.

Physiology and Biophysics: Venglarik CJ, Schultz BD, DeRoos AD, Singh AK, Bridges RJ (1996) Tolbutamide causes open channel blockade of cystic fibrosis transmembrane conductance regulator Cl- channels.Biophys J 70:2696-703. Chuck Venglarik was the one who introduced th power density analysis of multi-channel patches which was used to analyze the fast flickery tolbutamide block. My first introduction to large scale automated data analysis.

Cell Biology: Afink GB, Van Alewijk DC, De Roos AD, Van Zoelen EJ (1994) Lysophosphatidic acid and bradykinin have opposite effects on phenotypic transformation of normal rat kidney cells. J Cell Biochem 56:480-9. Some results from the IP3 measurements thal I did as an undergraduate student in van Zoelen’s lab were included.

Human Genetics: Berger W, Meindl A, de Leeuw B, de Roos A, van de Pol TJ, Meitinger T, van der Velde-Visser SD, Achatz H, Geurts van Kessel A, Cremers FP, Ropers HH (1992) Generation and characterization of radiation reduced cell hybrids and isolation of probes from the proximal short arm of the human X chromosome. Hum Genet 90:243-6. Some work I did as an undergraduate student in the lab of Hans-Hilger Ropers on the genetics of X-linked diseases such as Norrie’s disease.